A scaffold for small proteins

Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins

Chromosome higher order structure has been an enigma for over a century. The most important structural finding has been the presence of a chromosome scaffold composed of non-histone proteins; so-called scaffold proteins. However, the organization and function of the scaffold are still controversial. Here, we use three dimensional-structured illumination microscopy (3D-SIM) and focused ion beam/...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Scaffold proteins in cancer

Scaffold proteins are crucial regulators of many key signaling pathways that function by interacting with multiple members of a signaling pathway and tethering them into complexes. We recently identified novel scaffold proteins that respectively regulate p53 and ERK pathways in gastrointestinal tumors. ArhGAP30 is a member of the RhoGAP family that are known to regulate Rho GTPases and thereby ...

Filamin: A Family of Mechanosensory Scaffold Proteins

Eisosome proteins assemble into a membrane scaffold

Spatial organization of membranes into domains of distinct protein and lipid composition is a fundamental feature of biological systems. The plasma membrane is organized in such domains to efficiently orchestrate the many reactions occurring there simultaneously. Despite the almost universal presence of membrane domains, mechanisms of their formation are often unclear. Yeast cells feature promi...